Rheumatoid Arthritis

Plenge, Karlsson, Liao et al.

Discussed paper under review and how different diagrams of the NLP process need to be improved.

Major Depressive Disorder

Perlis et al.,

Perspective on how the original DBP relates to a new R01 that Perlis was awarded. The original DBP 2000 samples original goal of the DBP from which the GWAS would be drawn. The new R01 provides for additional samples and additional modeling. Long discussion about long-term curation of de-identified notes ensued. Several pitfalls were addressed.

Interesting commercial implementation of i2b2

J&J has made an interesting foray into creating a translational analytic platform using i2b2. This article from Bio-ITWorld summarizes an impressive bit of work led Eric Perakslis. They have pulled together multiple private and public data sources to help accelerate their discovery and validation process. Perhaps this presages a further push into trans-enterprise intelligence at the pharmaceutical companies?