DM DBP

Shan Shaw led discussion of early validation exercises (e.g. mortality prediction from various clinical characteristics)

This led to a discussion of the wholesale representation of the NLP concept derivatives of a data mart within the i2b2 database. This includes a discussion, for example, whether we should store modifiers with concepts or new compound concepts (that bury the explicit modifiers). The most important part of the discussion was the remarkably small contribution that negation seems to have to the performance of the NLP algorithms.

Roy Perlis: All Hands Meeting on Major Depression and Treatment Resistance (genetic basis)

Why study genetics of TRD?

Heritability of TRD estimated to be ~60% (styled in the manner of Visscher.

The Challenge:

1) Lasagna's Law

2) Establishing TRD requires multiple treatment trials (costly).

During the closed i2b2 MDD TRD DBP:

a) Developed high specificity for extremes of response (specificity of 95%)

b) Studied changes in CNV burden and MDD/TRD. Results are still preliminary.

c ) Clinical Goal: Risk Stratification

d) Discussed CNV changes

n

DM and CAD DBP's

Liao et al.

Several new faces introduced (see photo below) and Kat gave a quick update on Coronary Artery Disease phenotyping/

Ashwin discussed depression, anxiety in IBD (sample size ~5000). About 20% of the patients were depressed and various co-variates we assessed (for example TNF use was not significantly correlated to depression).

Zongqi presented the characteristics of the Multiple Sclerosis in the MS i2b2 Virtual Cohort.

Summary and videos from the SHRINE Conference

Thanks to Katia and Kerry Ann Foley, we now have a site summarizing the very successful SHRINE meeting that was held this Summer at Harvard. It includes videos of all the presentations.