Governance models

We met this morning to discuss several alternative governance models. Given the spreading use and an increasingly vibrant community, we will be developing an even more pro-active and long-term plan to support i2b2's continued growth. Details to be presenting at the Summer i2b2 AUG meeting.

Topic models and unsupervised NLP

Very nice presentation from Tim Miller today about work at i2b2 on this.

Review of Adaptive Lasso

Professor Cai reviewed for us the Adaptive Lasso function. She also provided the framework to understand the similarities between various machine learning formalisms (e.g. Hinge Loss function and SVM)

Also discussed the fundamental bias vs variance tradeoff. Approximation error (i.e. from selection from the feature space). Variance (i.e. sample error). If you have lower approximation error, for example, you can afford a high sample error (and vice versa).

Inflammation (DM,CAD,CVD)

Kat, Stan et al.,

Stan takes a birds eye view of the various views of cardiovascular morbiditird of our various cohorts. Such as non-fatal MI, non-fatal strokes, hospitalization for heart failure, cardiovascular death (fatal MI, fatal stroke), peripheral vascular disease), revascularizartion.

SHRINE & i2b2

Murphy, Churchil, Kohane et al

Reviewed the next steps in disseminating SHRINE and necessary architecture additions.

DM

Shaw walked us through the NLP analysis. Using a gold standard of 391 patients. Saw extremely good performance where NLP + codified data clearly domination NLP or codified data alone. Area Under the Curve was at least 98%. Quite remarkable.

HAPPY NEW YEAR 2012 - Both DBP Meeting

Shaw, Murphy, Plenge, Kohane, Karlson, Prilutsky, Doshi, Szolovits, Liao, Churchill, et al.

Reviewed the NLP on the cardiovascular data mart (340,000 patients).

Reviewed what is the right sample prep for our new studies (tending towards spinning down and storing the buffy coat and plasma fraction sepeartely and -70).

Kat presented results on PheWAS on the autoimmune panel.