Griffin Weber described the Profiles open source tool that is now being used world wide that was first developed for our work in Harvard Catalyst. It is used to find collaborators, create teams for research projects, study promotion and the processes of academia.
Professor Tianxi Cai ran a very interesting discussion about generating risk profiles for biomarkers and the problem in adjusting out the diseases that are along the causal pathway to mortality of those biomarkers. As a result of such an over adjustment, most biomarkers will give counter-conventional-wisdom associations.
Murphy, Bickel, Kohane, Simons, Churchill, Mendis. Wattanasin, Weber, Donahoe, MacFadden
Discussed the interaction between different governance models and how they interact with the architecture.
Profs Cai and Shaw led a discussion of the the CAD NLP algorithm and demonstrated how the different priors and different ascertainment biases of different clinics could affect the accuracy of the NLP classification. Also discussed counter-intuitive coefficients in the model which may reflect confounding by the treatments for CAD.
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Guergana's team: discussed speed issues.
cTAKES with full UMLS module takes about 150 notes/hour/core. Discussed various architectural tradeoffs.
10:14 AM, Mar 15, 2013
Jordan Smoller, co-PI of the MDD-SSRI-resistance i2b2 DBP presented today the paper he contributed to that made a lot of headlines regarding genomic variants shared across 5 psychiatric disorders.
