Karlson reviewed the i2b2/PGRN project on predicting response to disease modifying drugs in rheumatoid arthritis. This included adding functional status assessment to cTAKES. She articulated the first task is finding the best combination of structured and NLP-derived clinical variables that are predictive of disease activity. As an aside, Elizabeth noted that "Biologicals" have become first line thereapeutics in RA. Quite a change from what is in our EMR from 15 years ago.
Most of the session was a review of the use of the Knowtator tool on the rheumatoid arthritis corpus.
The remainder was focused on a discussion of the selection of the cohort with multiple sclerosis (MS) and a radiologically isolated precursor of MS (i.e. a radiologically made incidental diagnosis).
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