All hands meetings

Topic: Local i2b2-initiated federally funded spinoffs.

1.Kat Liao presented the RA DBP and the spinoff RA-CVD project. What is the relationship with risk for CAD/CVD risk in the general population (and the risk alleles) and that in RA. Our of 4453 in RA cohort (i2b2), 335 have CAD.

2. Jordan Smoller presented the Bipolar Disease NIMH grant. Reviewed the challenges of a very specific case definition. Claims codes alone seem to give positive predictive values (PPV) in the 20-50% range and the PPV of NLP is about 85% (with specificity of 95%).

3. Roy Perlis spoke about his R01 derived from the MDD-resistant-to-SSRI DBP. He is studying a MDD clinical and genetic risk risk algorithm/classifier. He is on the way to a 1500 population which represented 1/2 of all the drug response GWAS currently published in this particular domain?

4. Robert Plenge described the spinoff of the i2b2 RA DBP to the PGRN project. The project looks at genetic informants of treatment response and treatment toxicities. Involves Vanderbilt, Northwestern and Partners. Early result shows the portability of the NLP RA classifier.