Why study genetics of TRD?
Heritability of TRD estimated to be ~60% (styled in the manner of Visscher.
The Challenge:
2) Establishing TRD requires multiple treatment trials (costly).
During the closed i2b2 MDD TRD DBP:
a) Developed high specificity for extremes of response (specificity of 95%)
b) Studied changes in CNV burden and MDD/TRD. Results are still preliminary.
c ) Clinical Goal: Risk Stratification
d) Discussed CNV changes
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